Temozolomide is introduced for use in order to adult patients with newly diagnosed glioblastoma multiforme concomitantly with radiotherapy and then as a maintenance therapy.
The temozolomide 100 mg capsule is used for the treatment of adult patients with refractory anaplastic astrocytoma, i.e., patients who have noticed the disease progression on a medicine regimen containing nitrosourea and procarbazine.
Approval: Temozolomide is an alkylating agent and was developed by Malcolm Stevens and his team at Aston University in Birmingham, England.
In the months of January and August in 1999, Temozolomide was approved for medical use in the European Union and in the United States, respectively.
In February 2009, an intravenous formulation was also approved in the United States.
Dosage Form: Temozolomide comes in the form of capsules generically and under the brand name Temodar. Temozolomide can be taken by mouth as a capsule. A healthcare professional will decide the appropriate dose and best way to take the capsules. This drug should be administered exactly as prescribed. Capsules of temozolomide come in different strengths with different color caps.
Administer each day’s dose of temozolomide capsules at one time, through a full glass of water. Swallow the temozolomide capsules whole, without chewing, opening, or splitting the capsules. In case temozolomide capsules are accidentally opened/damaged, be careful not to inhale the powder from the capsules or get the powder on your skin or mucous membranes. In case contact with any of these areas takes place, promptly flush the area with the help of water.
Side Effects: Side effects of temozolomide are usually mild and not life threatening. The commonly reported side effects may include feeling sick, constipation, loss of appetite, hair loss, vomiting, headache, tiredness, seizures, rash, low white-blood-cell counts, and low blood platelet counts.
Cost: The temozolomide price in India may vary depending on the wholesaler or pharmacy and of course the brand you choose. The cost of temozolomide is around Rs. 8901 for a supply of 5 capsules.
