Nirmatrelvir is an orally available antiretroviral (ARV) 3C-like protease inhibitor. It is co-administered with ritonavir, which is a HIV protease inhibitor, significantly considered in this context to boost/enhance the potency of nirmatrelvir. Both nirmatrelvir and ritonavir should be considered antiviral monotherapy. The drug is active against SARS-CoV-2, including Alpha, Beta, Gamma, Delta and Omicron variants of concern.
Clinical Indication:
Individuals with confirmed non-severe COVID-19 and those at increased risk for hospital stay; and with symptoms less than five days.
Those at increased risk are typically those that lack COVID-19 vaccination, with older age or chronic complications, such as diabetes, hypertension, cardiac disease, chronic lung/kidney disease, obesity, cerebrovascular disease, dementia, mental disorder, immunosuppression (including HIV), and cancer.
Available Formulation and Storage:
The medicine nirmatrelvir must be co-administered with an HIV protease inhibitor named ritonavir and is co-packaged.
- Nirmatrelvir is supplied in 150 mg tablets.
- Ritonavir is supplied in 100 mg tablets.
In absence of co-administration, ritonavir will be responsible for resulting insufficient plasma concentrations of nirmatrelvir to get the required therapeutic effect.
Store co-packaged tablets of Nirmatrelvir and Ritonavir at room temperature (20 °C to 25 °C).
Dosage and Route of Administration:
Route: The route of administration is oral (taken by mouth). Tablets need to be gulped whole and not be opened, chewed,broken or crushed for dispersion.
Dose and Duration: In those with normal renal function, the proposed dose is 300 mg nirmatrelvir (two 150 mg tablets) with 100 mg ritonavir (one 100 mg tablet) taken together by mouth (orally) every 12 hours daily for a total of 5 consecutive days.
Nirmatrelvir-ritonavir does not require adjustment in those with hepatic impairment. Caution should be imposed when prescribed in those pre-existing liver conditions, liver enzyme abnormalities or hepatitis. This medicinal product should not be used in those with advanced liver disease.
An Overview of Ritonavir:
Ritonavir is a prescription medicinal product approved by the FDA for the treatment o f HIV infection in adults and children aged older than one month. Ritonavir is always considered in combination with other HIV medicinal products.
HIV medications can not cure HIV/AIDS, but taking a combination of HIV drugs (known as HIV regimen) each day helps individuals with HIV/AIDS live longer, healthier lives. These medicines are able to scale down the risk of HIV transmission.
Ritonavir typically supplied under the brand name Norvir. The medicine comes in the following forms and strengths:
- 100 mg Tablets
- 100 mg soft gelatin Capsules
- 80 mg/mL oral solution (An oral solution typically is a mixture of a medication and a liquid that can be taken by mouth).
- 100 mg of oral powder (The oral powder is mixed soft foods/liquids and then can be taken by mouth).
Availability in India:
People from all over the world (including India) can access nirmatrelvir-ritonavir and all other approved combination. IKRIS Pharma can supply this medicine at best price across the globe. Make an inquiry and we will help you calculate the total price to buy nirmatrelvir and ritonavir online and have it delivered to your location. Kindly contact us either via Email: info@ikrispharmanetwork.com, Or Call/WhatsApp: +91 8130290915, Or TOLL-FREE: 1800-889-1064.
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